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. 1983 Mar 1;157(3):1064-9.
doi: 10.1084/jem.157.3.1064.

Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen

J Cossman, L M Neckers, W J Leonard, W C Greene

Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen

J Cossman et al. J Exp Med. .

Abstract

Monoclonal antibodies J5, VIL-A1, and BA-3, known to react with the common acute lymphoblastic leukemia antigen (CALLA) were found to specifically stain normal human polymorphonuclear neutrophils (PMN). The antigen detected on PMN had a molecular weight (95,000-110,000 mol wt) close to that of CALLA (95,000-100,000 mol wt) and thus these surface membrane antigens are likely related, if not identical. The fluorescent staining intensity of PMN is comparable to that of CALLA-positive leukemic cells and the presence of PMN in patient samples could potentially produce false-positive results in diagnosis.

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