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. 1978 Jan 19;271(5642):223-5.
doi: 10.1038/271223a0.

Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine

G M Sheldrick, P G Jones, O Kennard, D H Williams, G A Smith

Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine

G M Sheldrick et al. Nature. .

Abstract

Vancomycin, a broad-spectrum antibiotic, inhibits the growth of cell walls by complex formation with peptides terminating in D-alanyl-D-alanine. The structure of vancomycin was determined by X-ray analysis of the degradation product CDP-I. A model of the complex is proposed based on this study and spectroscopic data.

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