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. 1976 Nov 6;2(7993):1001-4.
doi: 10.1016/s0140-6736(76)90837-0.

Activation of complement by the alternative pathway as a factor in the pathogenesis of periodontal disease

A C Allison, H U Schorlemmer

Activation of complement by the alternative pathway as a factor in the pathogenesis of periodontal disease

A C Allison et al. Lancet. .

Abstract

Dental plaque and a bacterium, Actinomyces viscosus, isolated from plaque that can reproduce periodontal disease in germ-free rats, are activators of complement by the alternative pathway. It is suggested that this process is involved in the pathogenesis of chronic inflammatory periodontal disease.

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