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. 1983 Sep;61(1):37-47.
doi: 10.1016/0022-510x(83)90053-9.

Nuclear membrane indentations in Huntington's chorea

R A Roos, G T Bots

Nuclear membrane indentations in Huntington's chorea

R A Roos et al. J Neurol Sci. 1983 Sep.

Abstract

Electron-microscopical examination of the nucleus accumbens, caudate nucleus and frontal cortex was performed in 21 patients with Huntington's disease (HD) and 21 age-matched controls. In HD, nuclear membrane indentations (NMI) were found in 25%, 29% and 20%, respectively, of the neurons of these areas. In the control group these figures were 4%, 4% and 38%, respectively. Possible pathogenetic mechanisms of the NMI are discussed.

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