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. 1983 Dec 19;33(25):2479-82.
doi: 10.1016/0024-3205(83)90155-8.

Induction of oral dyskinesias in naive rats by D1 stimulation

H Rosengarten, J W Schweitzer, A J Friedhoff

Induction of oral dyskinesias in naive rats by D1 stimulation

H Rosengarten et al. Life Sci. .

Abstract

Repetitious opening and closing of the mouth and high frequency clonic jaw movements were observed in rats challenged with dopamine agonists after acute treatment with sulpiride or a low dose of spiroperidol. SKF 38393, a specific D1 receptor agonist, alone, also induced these behaviors and cis-flupenthixol blocked them, evidence suggesting D1 dopamine receptor mediation.

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