Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983;81(4):327-31.
doi: 10.1007/BF00427571.

The effect of low doses of d-amphetamine on drug-induced hyperactivity in the mouse

J S Hussey, N D Vincent, J A Davies

The effect of low doses of d-amphetamine on drug-induced hyperactivity in the mouse

J S Hussey et al. Psychopharmacology (Berl). 1983.

Abstract

The effect of low doses (7.5-250 micrograms/kg) of d-amphetamine was studied on benztropine- or gamma-butyrolactone-induced hyperactivity in the mouse. Amphetamine 30-125 micrograms/kg significantly attenuated the drug-induced hyperactivity. This effect was antagonised by both cinanserin and p-chlorophenylalanine. The results suggest that low doses of d-amphetamine release 5-hydroxytryptamine, which in turn has an inhibitory effect on locomotor activity. This effect was masked at higher doses of d-amphetamine due to a release of dopamine.

PubMed Disclaimer

References

    1. Psychopharmacology (Berl). 1978 Dec 15;60(1):67-72 - PubMed
    1. Brain Res. 1976 Apr 23;106(2):257-69 - PubMed
    1. Biochem Pharmacol. 1976 Feb 15;25(4):447-51 - PubMed
    1. Br J Pharmacol. 1972 Nov;46(3):409-15 - PubMed
    1. Br J Pharmacol. 1983 Jan;78(1):137-42 - PubMed

LinkOut - more resources