In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim
- PMID: 6229216
- PMCID: PMC185938
- DOI: 10.1128/AAC.24.5.754
In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim
Abstract
Enoxacin is a new quinolone carboxylic acid compound. Its activity against 740 bacterial isolates was determined. It inhibited 90% Escherichia coli, Klebsiella sp., Aeromonas sp., Enterobacter spp., Serratia spp., Proteus mirabilis, and Morganella morganii at less than or equal to 0.8 micrograms/ml. The majority of Pseudomonas aeruginosa was inhibited by less than or equal to 3.1 micrograms/ml. Haemophilus spp. and Neisseria spp. were inhibited by less than 0.1 micrograms/ml. Although most Staphylococcus aureus were inhibited by 3.1 micrograms/ml, some streptococcal species had minimal inhibitory concentrations of 6.3 to 12.5 micrograms/ml and Bacteroides sp. had minimal inhibitory concentrations greater than or equal to 25 micrograms/ml. Activity of enoxacin and norfloxacin was similar. Enoxacin inhibited organisms resistant to cefotaxime, moxalactam, gentamicin, and piperacillin. Enoxacin was less active in urine at an acid pH than in broth, but serum did not decrease minimal inhibitory concentrations or minimal bactericidal concentrations. There was no major difference between minimal inhibitory concentrations and minimal bactericidal concentrations. Resistance frequency development was less than 10(-9) for most bacterial species.
Similar articles
-
In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.Antimicrob Agents Chemother. 1982 Jul;22(1):23-7. doi: 10.1128/AAC.22.1.23. Antimicrob Agents Chemother. 1982. PMID: 6214995 Free PMC article.
-
In-vitro activity of pefloxacin compared to enoxacin, norfloxacin, gentamicin and new beta-lactams.J Antimicrob Chemother. 1985 Jan;15(1):39-44. doi: 10.1093/jac/15.1.39. J Antimicrob Chemother. 1985. PMID: 3156112
-
In-vitro activity of ofloxacin, a quinolone carboxylic acid compared to other quinolones and other antimicrobial agents.J Antimicrob Chemother. 1985 Nov;16(5):563-74. doi: 10.1093/jac/16.5.563. J Antimicrob Chemother. 1985. PMID: 3865923
-
Comparative in vitro activities of enoxacin (CI-919, AT-2266) and eleven antipseudomonal agents against aminoglycoside-susceptible and -resistant Pseudomonas aeruginosa strains.Antimicrob Agents Chemother. 1984 Sep;26(3):417-8. doi: 10.1128/AAC.26.3.417. Antimicrob Agents Chemother. 1984. PMID: 6439116 Free PMC article.
-
A laboratory assessment of ciprofloxacin and comparable antimicrobial agents.Eur J Clin Microbiol. 1984 Aug;3(4):328-32. doi: 10.1007/BF01977488. Eur J Clin Microbiol. 1984. PMID: 6237900
Cited by
-
In vitro and in vivo antibacterial activities of the fluoroquinolone WIN 49375 (amifloxacin).Antimicrob Agents Chemother. 1985 Jan;27(1):4-10. doi: 10.1128/AAC.27.1.4. Antimicrob Agents Chemother. 1985. PMID: 3885845 Free PMC article.
-
Influence of quinolones on throat- and faecal flora of healthy volunteers.Pharm Weekbl Sci. 1987 Dec 11;9 Suppl:S41-4. doi: 10.1007/BF02075258. Pharm Weekbl Sci. 1987. PMID: 3438150
-
Selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes.Antimicrob Agents Chemother. 1984 Dec;26(6):797-801. doi: 10.1128/AAC.26.6.797. Antimicrob Agents Chemother. 1984. PMID: 6098219 Free PMC article.
-
Advances in the Synthesis and Biological Applications of Enoxacin-Based Compounds.Biomolecules. 2024 Nov 7;14(11):1419. doi: 10.3390/biom14111419. Biomolecules. 2024. PMID: 39595595 Free PMC article. Review.
-
Enoxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.Drugs. 1988 Jul;36(1):32-66. doi: 10.2165/00003495-198836010-00004. Drugs. 1988. PMID: 3063494 Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous