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. 1983 Dec 28;117(3):859-65.
doi: 10.1016/0006-291x(83)91675-3.

The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties

T G Flynn, M L de Bold, A J de Bold

The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties

T G Flynn et al. Biochem Biophys Res Commun. .

Abstract

A 28 amino acid peptide with diuretic and natriuretic activity has been purified from rat atrial muscle. The primary structure of this atrial peptide is H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly- (sequence in text) Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-(Arg)-Tyr-OH. The biological activity of this peptide is identical to that of atrial natriuretic factor and cardionatrin I isolated from rat atria.

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