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. 1978 Jan;30(1):28-37.

Efficiency and robustness of pedigree segregation analysis

R C Go, R C Elston, E B Kaplan

Efficiency and robustness of pedigree segregation analysis

R C Go et al. Am J Hum Genet. 1978 Jan.

Abstract

Different pedigree structures and likelihoods are examined to determine their efficiency for parameter estimation under one-locus models. For the cases simulated, family size has little effect; estimates based on unconditional likelihoods are generally more efficient than those based on conditional likelihoods. The proposed method of pedigree analysis under a one-locus model is found to be robust in the analysis of nuclear families: skewness of the data and polygenic inheritance will not lead to the spurious detection of major loci unless they occur simultaneously, and together with a moderate amount of environmental correlation among sibs.

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