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. 1978 Jan;30(1):46-58.

A genetic study of immunoglobulin E

J W Gerrard, D C Rao, N E Morton

A genetic study of immunoglobulin E

J W Gerrard et al. Am J Hum Genet. 1978 Jan.

Abstract

Path analysis gives evidence of genetic heritability (.425) for serum IgE levels. Complex segregation analysis indicates, in addition to significant polygenic heritability, a major regulatory locus RE, with homozygotes re/re maintaining persistently high levels of IgE. The gene frequency of re is .489, and the displacement is 1.67 standard deviations.

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