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. 1984 Mar;3(3):551-6.
doi: 10.1002/j.1460-2075.1984.tb01845.x.

Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins

B Burke, K Matlin, E Bause, G Legler, N Peyrieras, H Ploegh

Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins

B Burke et al. EMBO J. 1984 Mar.

Abstract

The effects of 1-deoxynojirimycin (dNM) and 1-deoxymannojirimycin (dMM), inhibitors of oligosaccharide trimming glucosidase I and mannosidase I, respectively, on the biosynthesis of vesicular stomatitis virus G protein, influenza virus hemagglutinin, and human class I histocompatibility antigens were investigated. Although the oligosaccharides of these membrane glycoproteins were greatly altered, neither dNM nor dMM interferred with their surface expression, as determined by a variety of assays, including accessibility to proteases and antibodies; neither did these drugs inhibit production of infectious virus particles.

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