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. 1984 Jan;16(1):73-8.
doi: 10.3109/00313028409067914.

Monoclonal antibodies against antigens of the human platelet surface: preparation and properties

H Zola, P J McNamara, I G Beckman, D A Brooks, P J Macardle, J Bradley, K Goodall, J Skinner, R Collins, M C Berndt

Monoclonal antibodies against antigens of the human platelet surface: preparation and properties

H Zola et al. Pathology. 1984 Jan.

Abstract

Three monoclonal antibodies, FMC24, 25 and 27, reactive with human platelets, are described. In normal blood the 3 antibodies are specific for platelets, but FMC27 reacts with leukemic blast cells in a proportion of acute leukemias. FMC25 precipitates the platelet membrane glycoprotein lb and a glycoprotein of molecular weight 22,000. The antibodies show different effects on platelet aggregation.

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