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. 1984 Apr 11;12(7):3057-68.
doi: 10.1093/nar/12.7.3057.

A DNA-recombinogenic activity in human cells

K Kenne, S Ljungquist
Free PMC article

A DNA-recombinogenic activity in human cells

K Kenne et al. Nucleic Acids Res. .
Free PMC article

Abstract

A DNA recombining protein has been partly purified from cell lines derived from patients suffering from the hereditary disease, Bloom's syndrome. The protein induces the formation of displacement loops in phi X174 RFI DNA molecules after the addition of single-stranded DNA fragments. A filter binding method and electron microscopy were used to determine the reaction. The recombinogenic protein is dependent on divalent cations and ATP for activity.

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