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. 1984 Jul;26(1):35-8.
doi: 10.1128/AAC.26.1.35.

Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs

H Mett, K Gyr, O Zak, K Vosbeck

Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs

H Mett et al. Antimicrob Agents Chemother. 1984 Jul.

Abstract

We have studied the action of various antimicrobial agents in microbiological media and in human duodeno-pancreatic secretions. In the latter medium, clioquinol exhibited a rapid bactericidal effect on both growing and stationary bacteria at concentrations near its MIC. However, it was merely bacteriostatic in microbiological media, even at high concentrations. Phanquinone, chlorquinaldol, and, to a lesser extent, also chloramphenicol and trimethoprim likewise displayed enhanced bactericidal activity in duodeno-pancreatic secretions, but various other antibacterial agents did not. These findings suggest that duodeno-pancreatic secretions contain a factor augmenting the antibacterial activity of a number of drugs.

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