doi: 10.1016/0304-3940(84)90062-4.
Does maximal serotonin N-acetyltransferase activity necessarily reflect maximal melatonin production in the rat pineal gland?
- PMID: 6237281
- DOI: 10.1016/0304-3940(84)90062-4
Item in Clipboard
Does maximal serotonin N-acetyltransferase activity necessarily reflect maximal melatonin production in the rat pineal gland?
Neurosci Lett.
.
Abstract
p-Chlorophenylalanine (PCPA) treatment reduced pineal 5-hydroxytryptamine (5-HT) levels by 68.9% of non-PCPA treated levels in intact rat pineal glands and by 95.9% of non-PCPA treated levels in adrenergically denervated rat pineal glands. Although isoproterenol stimulation resulted in increased activity of serotonin N-acetyltransferase (NAT) activity in all experimental groups, pineal melatonin production was maximal only in non-PCPA treated rats, suggesting that 5-HT concentrations may exert considerable influence on the level of melatonin production in the rat pineal gland, independent of the level of NAT activity.
Similar articles
-
The role of the intracellular and extracellular serotonin in the regulation of melatonin production in rat pinealocytes.J Pineal Res. 1997 Sep;23(2):63-71. doi: 10.1111/j.1600-079x.1997.tb00337.x. J Pineal Res. 1997. PMID: 9392444
-
Interaction between pargyline, a monoamine oxidase inhibitor, and beta-adrenergic receptors in the rat pineal gland.Prog Clin Biol Res. 1982;92:95-105. Prog Clin Biol Res. 1982. PMID: 6287499
-
Reciprocal relationship between the concentrations of serotonin and the activity of serotonin-N-acetyltransferase in rat pineal glands in culture.Endocr Res Commun. 1981;8(1):25-44. doi: 10.1080/07435808109065981. Endocr Res Commun. 1981. PMID: 6263577 No abstract available.
-
Circadian rhythms of indoleamines and serotonin N-acetyltransferase activity in the pineal gland.Mol Cell Biochem. 1979 Sep 28;27(1):57-66. doi: 10.1007/BF00849279. Mol Cell Biochem. 1979. PMID: 229406 Review. No abstract available.
-
Rhythms in ocular and pineal N-acetyltransferase: a portrait of an enzyme clock.Comp Biochem Physiol A Comp Physiol. 1983;75(2):123-9. doi: 10.1016/0300-9629(83)90057-9. Comp Biochem Physiol A Comp Physiol. 1983. PMID: 6135530 Review. No abstract available.
Cited by
-
Ethanol ingestive behavior as a function of central neurotransmission.Experientia. 1989 May 15;45(5):444-52. doi: 10.1007/BF01952026. Experientia. 1989. PMID: 2566510 Review.
-
Neither prolactin nor growth hormone restore the nocturnal rise in pineal N-acetyltransferase activity or melatonin content in hypophysectomized rats.Experientia. 1988 Jun 15;44(6):509-11. doi: 10.1007/BF01958931. Experientia. 1988. PMID: 3378593
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
