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. 1984 Oct;98(10):484-6.

[Action of epidermal chalone on the vaginal epithelial cell proliferation in ovariectomized mice stimulated by 17 beta-estradiol]

[Article in Russian]
K M Svetikova, S A Ketlinskiĭ
  • PMID: 6238638

[Action of epidermal chalone on the vaginal epithelial cell proliferation in ovariectomized mice stimulated by 17 beta-estradiol]

[Article in Russian]
K M Svetikova et al. Biull Eksp Biol Med. 1984 Oct.

Abstract

It has been shown that the DNA synthesis inhibitory effect of chalone on the vaginal epithelium of ovariectomized mice administered epidermal chalone three times (8, 4 and 1 h before 17-beta-estradiol injection) is dependent on chalone injection made 1 h before hormone injection. The decrease in the number of DNA synthesizing cells induced by 3-fold injection of chalone during 2 days is linked with the reduction in the level of exogenous estrogen in ovariectomized mice rather than with the duration of epidermal chalone action.

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