Partial protection against streptozotocin-induced hyperglycaemia by superoxide dismutase linked to polyethylene glycol
- PMID: 6239493
- DOI: 10.1530/acta.0.1070390
Partial protection against streptozotocin-induced hyperglycaemia by superoxide dismutase linked to polyethylene glycol
Abstract
To test the possible role of superoxide radicals in the diabetogenic action of streptozotocin, blood glucose levels were measured in mice after a single high-dose (150 mg/kg body weight) or multiple low-dose (40 mg/kg for 5 days) injections of streptozotocin. Pretreatment 6 h before streptozotocin with 250-300 mg/kg superoxide dismutase coupled to polyethylene glycol reduced the hyperglycaemic response in mice injected with a single dose of streptozotocin. The blood glucose levels after multiple low doses of streptozotocin were not affected by superoxide dismutase-polyethylene glycol. Enzymatically inactive superoxide dismutase did not affect the development of hyperglycaemia. The results suggest that superoxide radicals may play a role in the diabetogenic action of streptozotocin injected as a high-dose single bolus.
Similar articles
-
Protection against streptozotocin-induced diabetes by superoxide dismutase.Diabetologia. 1980 Jan;18(1):55-8. doi: 10.1007/BF01228303. Diabetologia. 1980. PMID: 6444904
-
Protective effects of retinyl palmitate on streptozotocin- and alloxan-induced beta cell toxicity and diabetes in the rat.Res Commun Chem Pathol Pharmacol. 1989 Jan;63(1):27-44. Res Commun Chem Pathol Pharmacol. 1989. PMID: 2521747
-
Diabetes induced with multiple subdiabetogenic doses of streptozotocin: lack of protection by exogenous superoxide dismutase.Diabetes. 1981 Aug;30(8):634-8. doi: 10.2337/diab.30.8.634. Diabetes. 1981. PMID: 6454601
-
Polyethylene glycol-conjugated superoxide dismutase attenuates reperfusion injury when administered twenty-four hours before ischemia.J Thorac Cardiovasc Surg. 1992 Dec;104(6):1597-601. J Thorac Cardiovasc Surg. 1992. PMID: 1453723
-
Inability of polyethylene-glycol substituted copper- and zinc-containing superoxide dismutase to protect mice against radiation lethality.Acta Oncol. 1987;26(6):483-7. doi: 10.3109/02841868709113722. Acta Oncol. 1987. PMID: 3446246
Cited by
-
Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models.Lab Anim. 2011 Jul;45(3):131-40. doi: 10.1258/la.2010.010090. Epub 2011 Apr 8. Lab Anim. 2011. PMID: 21478271 Free PMC article. Review.
-
Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.J Clin Invest. 2009 Nov;119(11):3246-56. doi: 10.1172/JCI38817. Epub 2009 Oct 1. J Clin Invest. 2009. PMID: 19805912 Free PMC article.
-
Oxidative stress and beta-cell dysfunction.Pflugers Arch. 2010 Sep;460(4):703-18. doi: 10.1007/s00424-010-0862-9. Epub 2010 Jul 23. Pflugers Arch. 2010. PMID: 20652307 Review.
-
Oxidative stress as a mechanism of diabetes in diabetic BB prone rats: effect of secoisolariciresinol diglucoside (SDG).Mol Cell Biochem. 2000 Jun;209(1-2):89-96. doi: 10.1023/a:1007079802459. Mol Cell Biochem. 2000. PMID: 10942205
-
Lipid peroxidation and activity of antioxidant enzymes in diabetic rats.Mol Cell Biochem. 1995 Oct 18;151(2):113-9. doi: 10.1007/BF01322333. Mol Cell Biochem. 1995. PMID: 8569756
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical