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. 1978 Jan;25(1):20-5.
doi: 10.1007/BF03006778.

Effect of anaesthetic agents on the ionic composition of cerebrospinal fluid following total cerebral ischaemia

J G Wade, S C Sørenson

Effect of anaesthetic agents on the ionic composition of cerebrospinal fluid following total cerebral ischaemia

J G Wade et al. Can Anaesth Soc J. 1978 Jan.

Abstract

Total cerebral ischaemia in rats caused a marked increase in the cisternal CSF potassium concentration but little change in CSF sodium or chloride concentration. The anaesthetic techniques studied (pentobarbitone, halothane/oxygen and nitrous oxide/oxygen/relaxant) did not effect the potassium increase following cerebral ischaemia. We conclude that the mechanism of barbiturate protection following cerebral ischaemia is different from that of hypothermia.

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