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Comparative Study
. 1984 Dec:62 ( Pt 6):743-54.
doi: 10.1038/icb.1984.70.

Effect of an iron-chelating agent on lymphocyte proliferation

N Bowern, I A Ramshaw, P Badenoch-Jones, P C Doherty
Comparative Study

Effect of an iron-chelating agent on lymphocyte proliferation

N Bowern et al. Aust J Exp Biol Med Sci. 1984 Dec.

Abstract

The effect of the iron-chelating agent desferrioxamine on lymphocyte proliferation has been studied. Desferrioxamine at concentrations of 15 microM totally inhibited the proliferation of Concanavalin A-stimulated lymphocytes, whereas iron-saturated desferrioxamine was ineffective. Other metal salts, however, had little or no effect on the inhibition induced by this drug. Desferrioxamine was more effective at suppressing proliferation of T lymphocytes than B lymphocytes and additionally suppressed mixed lymphocyte cultures and the generation of cytotoxic T cells.

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