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. 1984 Oct-Dec;28(4):259-67.

Role of 5-HT on increased permeability of blood-brain barrier under heat stress

H S Sharma, P K Dey
  • PMID: 6242051

Role of 5-HT on increased permeability of blood-brain barrier under heat stress

H S Sharma et al. Indian J Physiol Pharmacol. 1984 Oct-Dec.

Abstract

Exposure of young rats (9-10 wks) to chronic summer heat (36 degrees C) or acute heat (38 degrees C 4hr) increased the BBB permeability to Evans blue albumin complex (MW 68,000) and 131I-sodium (MW 154) in different brain regions which correlated well with the increased level of 5-HT in plasma and brain. This increased permeability of BBB and the increased 5-HT level were prevented by pretreatment with p-CPA, indomethacin and diazepam. Cyproheptadine and vinblastine pretreatment however, prevented only the increased permeability of BBB, the plasma and brain 5-HT level continued to remain high. These results indicate a probable role of 5-HT as one of the factors leading to the increased permeability of BBB in young rats following heat stress.

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