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. 1980 Feb;124(2):851-4.

T cell-mediated immunity to oncornavirus-induced tumors. II. Ability of different T cell sets to prevent tumor growth in vivo

J C Leclerc, H Cantor
  • PMID: 6243333

T cell-mediated immunity to oncornavirus-induced tumors. II. Ability of different T cell sets to prevent tumor growth in vivo

J C Leclerc et al. J Immunol. 1980 Feb.

Abstract

These studies demonstrate that two different types of protective immunologic reactions are generated in mice after inoculation with M.MSV. Type I protection, mediated by Ly1 cells, prevents MSV-induced sarcomas but has no effect on the growth of MLV+ lymphomas. This anti-MSV protection reflects induction of antivirion antibody and delayed type hypersensitivity reaction. Type II protection is mediated by Ly23 cells and prevents the growth of an MLV+ lymphoma, but has little or no protective effects against MSV-induced sarcomas. This "type II" reaction is directly related to CTL activity. The implications of these two protective reaction are discussed.

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