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. 1980 Jan 17;283(5744):264-7.
doi: 10.1038/283264a0.

Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro

L L Rubin, S M Schuetze, C L Weill, G D Fischbach

Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro

L L Rubin et al. Nature. .

Abstract

The appearance of acetylcholinesterase (AChE) at newly formed nerve-muscle synapses depends on synaptic transmission. Synapses form when cultures are grown in the presence of acetylcholine receptor antagonists, but AChE does not accumulate at these synapses. The important component of transmission seems to be muscle activity. Treatment with dibutyryl cyclic GMP mimics muscle activity, directly inducing synaptic AChE appearance.

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