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. 1980 Jan 25;61(2):175-7.
doi: 10.1016/0014-2999(80)90160-0.

Paradoxical effect of naloxone on nitrous oxide analgesia in man

M A Gillman, L Kok, F J Lichtigfeld

Paradoxical effect of naloxone on nitrous oxide analgesia in man

M A Gillman et al. Eur J Pharmacol. .

Abstract

The effect of naloxone on nitrous oxide analgesia in man has been investigated. The paradoxical response so obtained indicates the possibility of a dural system mediating the pain response in man. These results support previous animal experiments indicating that nitrous oxide analgesia is mediated by the opiate receptors.

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