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. 1980 Feb 14;283(5748):625-9.
doi: 10.1038/283625a0.

Cellular site of opiate dependence

H O Collier

Cellular site of opiate dependence

H O Collier. Nature. .

Abstract

Experiments on whole animals, guinea pig isolated ileum, individual neurones in situ and cultured neuroblastoma--glioma hybrid cells indicate that opiate dependence and associated tolerance develop within neurones bearing specific opiate receptors (opiate-sensitive neurones). The essential change appears to be an hypertrophy of the cyclic AMP system, in response to inhibition by opiate of a neuronal adenylate cyclase.

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