Plasma ACTH, cortisol, LH, FSH, testosterone, and dihydrotestosterone responses to bromocriptine in normal men

Abstract

The effects of an initial oral 2.5 mg dose of bromocriptine and of a similar dose after treatment with 2.5--5 mg daily for one week on plasma concentrations of ACTH, cortisol, LH, FSH, testosterone, and dihydrotestosterone were studied in normal men. In addition to its suppressive effects on plasma concentrations of prolactin and catecholamines which have been reported previously, a single dose of bromocriptine produced small increases in plasma ACTH and cortisol. Neither a single dose of bromocriptine nor treatment for one week altered plasma concentrations of LH and FSH. Plasma concentrations of testosterone and dihydrotestosterone were not altered by a single dose of bromocriptine, but small increases in both were noted in some subjects after treatment for one week.