Regulation of genes coding for enzyme constituents of the bacterial phosphotransferase system
- PMID: 6245053
- PMCID: PMC293672
- DOI: 10.1128/jb.141.2.658-663.1980
Regulation of genes coding for enzyme constituents of the bacterial phosphotransferase system
Abstract
Regulation of the synthesis of the proteins of the phosphoenolpyruvate:sugar phosphotransferase system was systematically studied in wild-type and mutant strains of Salmonella typhimurium and Escherichia coli. The results suggest that enzyme I and HPr as well as the glucose-specific and the mannose-specific enzymes II are synthesized by a mechanism which depends on (i) cyclic adenosine monophosphate and its receptor protein; (ii) extracellular inducer; (iii) the sugar-specific enzyme II complex which recognizes the inducing sugar; and (iv) the general energy-coupling proteins of the phosphotransferase system, enzyme I and HPr.
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