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. 1980 Mar;141(3):1258-63.
doi: 10.1128/jb.141.3.1258-1263.1980.

Salmonella typhimurium mutants defective in acetohydroxy acid synthases I and II

K J Shaw, C M Berg, T J Sobol

Salmonella typhimurium mutants defective in acetohydroxy acid synthases I and II

K J Shaw et al. J Bacteriol. 1980 Mar.

Abstract

An analysis of transposon-induced mutants shows that Salmonella typhimurium possesses two major isozymes of acetohydroxy acid synthase, the enzymes which mediate the first common step in isoleucine and valine biosynthesis. A third (minor) acetohydroxy acid synthase is present, but its significance in isoleucine and valine synthesis may be negligible. Mutants defective in acetohydroxy acid synthase II (ilvG::Tn10) require isoleucine, alpha-ketobutyrate, or threonine for growth, a mutant defective in acetohydroxy acid synthase I (ilvB::Tn5) is a prototroph, and a double mutant (ilvG::Tn10 ilvB::Tn5) requires isoleucine plus valine for growth.

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