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. 1980 Jun 10;255(11):4976-9.

Decatenation of kinetoplast DNA by topoisomerases

J C Marini, K G Miller, P T Englund
  • PMID: 6246090
Free article

Decatenation of kinetoplast DNA by topoisomerases

J C Marini et al. J Biol Chem. .
Free article

Abstract

Kinetoplast DNA is the mitochondrial DNA of trypanosomatids such as Crithidia fasciculata. This DNA is in the form of networks containing thousands of DNA circles which are apparently catenated (interlocked). Some topoisomerases, such as T4 phage topoisomerase and DNA gyrase, catalyze a decatenation of the networks to form individual covalently closed circles.

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