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. 1980 Feb;102(2):113-7.
doi: 10.1002/jcp.1041020203.

Concanavalin A induces an intraluminal alkalinization of thymocyte membrane vesicles

R B Mikkelsen, R Schmidt-Ullrich, D F Wallach

Concanavalin A induces an intraluminal alkalinization of thymocyte membrane vesicles

R B Mikkelsen et al. J Cell Physiol. 1980 Feb.

Abstract

Weak acid distribution methods demonstrate that mitogenic levels of concanavalin A induce an intravesicular alkalinization of isolated thymocyte membrane vesicles. Experiments with chemical reagents that crosslink the high affinity concanavalin A receptor and extensive correlation with known cellular events suggest that a "membrane Bohr effect" may participate in the initiation of mitogenesis.

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