doi: 10.1073/pnas.77.4.1877.
A mechanism for RNA splicing
- PMID: 6246511
- PMCID: PMC348611
- DOI: 10.1073/pnas.77.4.1877
Item in Clipboard
A mechanism for RNA splicing
Proc Natl Acad Sci U S A.
1980 Apr.
Abstract
The most abundant of the stable small nuclear RNAs of eukaryotic cells, U-1 small nuclear RNA, is exactly complementary to the consensus sequences at RNA splice sites. We propose that this RNA is the recognition component of the nuclear RNA splicing enzyme and forms base pairs with both ends of an intron so as to align them for cutting and splicing.
Similar articles
-
Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing.Cell. 1979 Sep;18(1):85-92. doi: 10.1016/0092-8674(79)90356-8. Cell. 1979. PMID: 228860 No abstract available.
-
Novel models for RNA splicing that involve a small nuclear RNA.Proc Natl Acad Sci U S A. 1981 Jul;78(7):4471-4. doi: 10.1073/pnas.78.7.4471. Proc Natl Acad Sci U S A. 1981. PMID: 6170064 Free PMC article.
-
Base-pairing interactions between small nuclear RNAs and nuclear RNA precursors as revealed by psoralen cross-linking in vivo.Cell. 1981 Nov;26(3 Pt 1):363-70. doi: 10.1016/0092-8674(81)90205-1. Cell. 1981. PMID: 6173132
-
Small RNAs in HnRNP fibrils and their possible function in splicing.Mol Biol Rep. 1981 May 22;7(1-3):31-9. doi: 10.1007/BF00778730. Mol Biol Rep. 1981. PMID: 6166851 Review.
-
Pre-mRNA splicing.Annu Rev Genet. 1986;20:671-708. doi: 10.1146/annurev.ge.20.120186.003323. Annu Rev Genet. 1986. PMID: 2880558 Review. No abstract available.
Cited by
-
Alteration by heat shock and immunological characterization of Drosophila small nuclear ribonucleoproteins.J Cell Biol. 1989 Jun;108(6):2007-16. doi: 10.1083/jcb.108.6.2007. J Cell Biol. 1989. PMID: 2525559 Free PMC article.
-
Cloning of the human cDNA for the U1 RNA-associated 70K protein.EMBO J. 1986 Dec 1;5(12):3209-17. doi: 10.1002/j.1460-2075.1986.tb04631.x. EMBO J. 1986. PMID: 3028775 Free PMC article.
-
Purification of the individual snRNPs U1, U2, U5 and U4/U6 from HeLa cells and characterization of their protein constituents.EMBO J. 1986 Dec 20;5(13):3509-16. doi: 10.1002/j.1460-2075.1986.tb04676.x. EMBO J. 1986. PMID: 2951249 Free PMC article.
-
Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites.Mol Cell. 2018 Sep 20;71(6):1012-1026.e3. doi: 10.1016/j.molcel.2018.07.033. Epub 2018 Aug 30. Mol Cell. 2018. PMID: 30174293 Free PMC article.
-
A novel role of U1 snRNP: Splice site selection from a distance.Biochim Biophys Acta Gene Regul Mech. 2019 Jun;1862(6):634-642. doi: 10.1016/j.bbagrm.2019.04.004. Epub 2019 Apr 28. Biochim Biophys Acta Gene Regul Mech. 2019. PMID: 31042550 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
