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Comparative Study
. 1980 Mar 1;185(3):775-7.
doi: 10.1042/bj1850775.

Novel inhibitors of poly(ADP-ribose) synthetase

M R Purnell, W J Whish
Comparative Study

Novel inhibitors of poly(ADP-ribose) synthetase

M R Purnell et al. Biochem J. .

Abstract

In a search for new inhibitors of the nuclear enzyme poly(ADP-ribose) synthetase, it was found that various benzamides substituted in the 3-position were the most inhibitory compounds found to date. Two of the benzamides, 3-aminobenzamide and 3-methoxybenzamide, were found to be competitive inhibitors, with Ki values or less than 2 microM.

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References

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