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. 1980 May;77(5):2551-4.
doi: 10.1073/pnas.77.5.2551.

Subclasses of external adenosine receptors

C Londos, D M Cooper, J Wolff

Subclasses of external adenosine receptors

C Londos et al. Proc Natl Acad Sci U S A. 1980 May.

Abstract

Cell surface adenosine receptors mediate either stimulation or inhibition of adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], and the receptors that mediate these different responses can be discriminated with selected adenosine analogs. 5'-N-Ethylcarboxamide-adenosine is a more potent agonist at stimulatory receptors (Ra) than is N6-phenylisopropyladenosine, whereas the reverse potency order is seen with inhibitory receptors (Ri). The potency of adenosine is intermediate between the potencies of these two analogs. The relative potencies of adenosine receptor agonists are maintained in physiological responses in intact cells, such as steroidogenesis and inhibition of lipolysis. As with adrenergic receptors, subclasses of adenosine receptors differ functionally and pharmacologically.

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References

    1. J Biol Chem. 1971 Mar 25;246(6):1849-56 - PubMed
    1. J Biol Chem. 1973 Sep 10;248(17):6239-45 - PubMed
    1. Mol Pharmacol. 1970 Jan;6(1):13-23 - PubMed
    1. Anal Biochem. 1974 Apr;58(2):541-8 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Aug;71(8):3087-90 - PubMed