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. 1980 May;77(5):2989-93.
doi: 10.1073/pnas.77.5.2989.

In vitro construction of a B-tropic virus by recombination: B-tropism is a cryptic phenotype of xenotropic murine retroviruses

J W Gautsch, J H Elder, F C Jensen, R A Lerner

In vitro construction of a B-tropic virus by recombination: B-tropism is a cryptic phenotype of xenotropic murine retroviruses

J W Gautsch et al. Proc Natl Acad Sci U S A. 1980 May.

Abstract

A B-tropic virus was isolated in vitro from the progeny of mouse cells doubly infected with N-tropic and xenotropic murine leukemia viruses. Biological and structural evidence is presented suggesting that the phenotypically silent structural marker for B-tropism, expressed by the xenotropic virus p30, was transferred to an N-ecotropic virus via recombination, thus resulting in the expression of a B-ecotropic murine leukemia virus.

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