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. 1980 May;45(1):45-52.
doi: 10.1007/BF00303294.

Effects of diethyldithiocarbamate and penicillamine on the tissue distribution of 63NiCl2 in mice

A Oskarsson, H Tjälve

Effects of diethyldithiocarbamate and penicillamine on the tissue distribution of 63NiCl2 in mice

A Oskarsson et al. Arch Toxicol. 1980 May.

Abstract

The effects of sodium diethyldithiocarbamate and DL-penicillamine on the fate of 63Ni2+ in mice injected with 63NiCl2 were studied by whole body autoradiography and liquid scintillation counting. Sodium diethyldithiocarbamate caused a retention and redistribution of 63Ni2+ in the tissues. DL-penicillamine decreased the 63Ni2+-concentration in the tissues. The nickel-diethyldithiocarbamate complex is lipophilic, whereas the nickel-DL-penicillamine complex is hydrophilic, and these differences in chemical properties may determine the different effects which these chelating agents have on the fate of Ni2+.

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