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. 1980 May;45(1):61-5.
doi: 10.1007/BF00303296.

Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein

M Younes, C P Siegers

Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein

M Younes et al. Arch Toxicol. 1980 May.

Abstract

Dithiocarb and (+)-cyanidanol-3-prevented paracetamol-induced liver injury in rats in vivo. Both, as well as two other antihepatotoxic agents, deanol and DMSO, inhibited covalent binding of [3H]-paracetamol to rat liver microsomal proteins in vitro. Dithiocarb and (+)-cyanidanol-3 were the most effective inhibitors. The concentrations of the antidotes yielding 50% inhibition (I50) valued 1 . 8 x 10(-5) M for dithiocarb and 2 . 1 x 10(-5) M for (+)-cyanidanol-3.

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