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. 1980;10 Suppl 1(Suppl 1):21S-24S.
doi: 10.1111/j.1365-2125.1980.tb04900.x.

Pharmacology of guanfacine

G Scholtysik

Pharmacology of guanfacine

G Scholtysik. Br J Clin Pharmacol. 1980.

Abstract

1. The pharmacological effects of the centrally acting antihypertensive drug guanfacine are reviewed. 2. The drug lowers systemic blood pressure in hypertensive rats dose-dependently after oral application of 0.3-5 mg/kg. 3. Evidence is presented that guanfacine produces its antihypertensive action by a specific stimulation of central alpha-adrenoceptors. 4. Certain pharmacological differences between clonidine and guanfacine are discussed.

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