Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Jul;69(3):519-25.
doi: 10.1111/j.1476-5381.1980.tb07043.x.

Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: prostanoid structure-activity relationships

I A Blair, C N Hensby, J MacDermot

Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: prostanoid structure-activity relationships

I A Blair et al. Br J Pharmacol. 1980 Jul.

Abstract

1 Prostacyclin activates adenylate cyclase of the NCB-20 neuronal hybrid cell line. 2 There is a guanosine 5'-triphosphate requirement for the activation of adenylate cyclase by 5,6 beta-dihydroprostacyclin (a stable analogue of prostacyclin). 3 Steady-state kinetic analysis of the activation of adenylate cyclase by 5,6 beta-dihydroprostacyclin suggests a simple non-cooperative bimolecular interaction between the ligand and single receptor population. 4 Structure-activity relationships of selected prostanoids elucidated certain functional requirements for activation of adenylate cyclase.

PubMed Disclaimer

References

    1. Nat New Biol. 1972 Feb 23;235(60):225-31 - PubMed
    1. Biochem Pharmacol. 1972 Nov 1;21(21):2841-7 - PubMed
    1. Nature. 1974 Mar 1;248(5443):24-7 - PubMed
    1. Anal Biochem. 1974 Apr;58(2):541-8 - PubMed
    1. Biochim Biophys Acta. 1975 Apr 7;385(2):275-80 - PubMed

MeSH terms

LinkOut - more resources