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. 1980 Jun 19;285(5766):550-4.
doi: 10.1038/285550a0.

Sequence of retrovirus provirus resembles that of bacterial transposable elements

K Shimotohno, S Mizutani, H M Temin

Sequence of retrovirus provirus resembles that of bacterial transposable elements

K Shimotohno et al. Nature. .

Abstract

The nucleotide sequences of the terminal regions of an infectious integrated retrovirus cloned in the modified lambda phage cloning vector Charon 4A have been elucidated. There is a 569-base pair direct repeat at both ends of the viral DNA. The cell-virus junctions at each end consist of a 5-base pair direct repeat of cell DNA next to a 3-base pair inverted repeat of viral DNA. This structure resembles that of a transposable element and is consistent with the protovirus hypothesis that retroviruses evolved from the cell genome.

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