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. 1980 Jun;17(6):954-6.
doi: 10.1128/AAC.17.6.954.

In vitro activity of mecillinam against anaerobic bacteria

G E Steinkraus, L R McCarthy

In vitro activity of mecillinam against anaerobic bacteria

G E Steinkraus et al. Antimicrob Agents Chemother. 1980 Jun.

Abstract

A microtiter broth dilution method was employed to determine the in vitro activity of mecillinam against 201 recent clinical isolates of anaerobic bacteria. Both the anaerobic gram-positive and anaerobic gram-negative bacilli displayed a wide range of minimal inhibitory concentrations of mecillinam; most strains were resistant to the antibiotic. The anaerobic cocci exhibited a narrower range of minimal inhibitory concentrations than were observed with other anaerobes, but also exhibited mecillinam resistance. As a single drug, mecillinam does not appear to be an effective antimicrobial agent against anaerobic bacteria.

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