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. 1980 Oct 15;36(10):1198-9.
doi: 10.1007/BF01976126.

Stimulation of pyruvate carboxylation by gastric secretagogues

E de Bohórquez, J Chacín

Stimulation of pyruvate carboxylation by gastric secretagogues

E de Bohórquez et al. Experientia. .

Abstract

Pyruvate carboxylation was stimulated by 2 gastric secretagogues, histamine and dibutyryl cyclic AMP, and by butyrate. Thiocyanate, an inhibitor of acid secretion, produced a slight decrease. Avidin significantly reduced acid secretion and this effect was overcome by biotin and oxalacetate. The results suggest that carboxylation of pyruvate is one of the reactions controlling oxidative metabolism and acid secretion in toad gastric mucosa.

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