doi: 10.7164/antibiotics.33.636.
Action of streptothricin F on ribosomal functions
- PMID: 6252135
- DOI: 10.7164/antibiotics.33.636
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Action of streptothricin F on ribosomal functions
J Antibiot (Tokyo).
1980 Jun.
Free article
Abstract
The effect of streptothricin F on elongation factor-dependent and on elongation factor-free translation systems was studied. Streptothricin F inhibits factor-dependent as well as factor-free polypeptide synthesis. The results suggest that streptothricin F inhibits polypeptide synthesis via interaction with the ribosome. In partial reactions streptothricin F impairs EF-G-dependent translocation and to a lesser extent EF-Tu-dependent binding of aa-RNA to the ribosome, while it does not affect peptide bond formation significantly.
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