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Case Reports
. 1980 Oct 15;46(8):1843-8.
doi: 10.1002/1097-0142(19801015)46:8<1843::aid-cncr2820460823>3.0.co;2-c.

Melanocytic bronchial carcinoid tumor

M S Cebelin
Case Reports

Melanocytic bronchial carcinoid tumor

M S Cebelin. Cancer. .

Abstract

A melanin- and serotonin-producing bronchial carcinoid tumor is described. Melanin synthesis by neoplastic cells also containing electron-dense core (neurosecretory granules was documented by electron microscopy and serotonin content was found by biochemical assay to be 201.2 micrograms/g wet weight of tissue. Simultaneous demonstration of "endocrine" properties with characteristics of a cell of neural-crest origin provides strongly confirmatory evidence for the APUD cell theory of Pearse and makes an interesting commentary in regard to general theories of neoplasia.

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