Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Oct 10;8(19):4393-404.
doi: 10.1093/nar/8.19.4393.

The 5' flanking region of human epsilon-globin gene

F E Baralle, C C Shoulders, S Goodbourn, A Jeffreys, N J Proudfoot
Free PMC article

The 5' flanking region of human epsilon-globin gene

F E Baralle et al. Nucleic Acids Res. .
Free PMC article

Abstract

The structural analysis of the 2.0 kb region upstream from the epsilon-globin gene has been carried out. A genomic DNA map around the gene was worked out in some detail to ensure that the cloned DNA was representative of the actual chromosomal arrangement. Furthermore, a new technique was developed to precisely map a reiterated DNA sequence present 1.5 kb to the 5' side of the gene. The complete nucleotide sequence of the 2.0 kb 5' flanking region was then determined and overlapped with the gene. The sequence included the reiterated DNA sequence which is homologous to the so-called AluI family of repeats. Unusual stretches of sequence 50 nucleotides long, where A + T represent about 90% of the bases, are present at both the 5' and 3' sides of the repeat.

PubMed Disclaimer

References

    1. Cell. 1976 Jun;8(2):163-82 - PubMed
    1. J Mol Biol. 1976 Sep 25;106(3):773-90 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4 - PubMed
    1. J Mol Biol. 1977 Oct 5;115(4):571-89 - PubMed
    1. J Mol Biol. 1977 Oct 5;115(4):591-601 - PubMed

Associated data