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. 1980 Apr 11;8(7):1499-504.
doi: 10.1093/nar/8.7.1499.

DNA methylation and the frequency of CpG in animal DNA

A P Bird
Free PMC article

DNA methylation and the frequency of CpG in animal DNA

A P Bird. Nucleic Acids Res. .
Free PMC article

Abstract

An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate abnormally frequently to T. This tendency is the likely cause of the CpG deficiency in heavily methylated genomes.

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References

    1. Nucleic Acids Res. 1980 Apr 11;8(7):1485-97 - PubMed
    1. Nature. 1977 Apr 7;266(5602):533-6 - PubMed
    1. Nucleic Acids Res. 1979 Jul 11;6(9):2987-95 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1966;31:737-48 - PubMed
    1. Nucleic Acids Res. 1978 Sep;5(9):3231-6 - PubMed