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Comparative Study
. 1980 Jul;77(7):3831-5.
doi: 10.1073/pnas.77.7.3831.

Comparative sequence analysis of the inverted terminal repetitions from different adenoviruses

M Shinagawa, R Padmanabhan
Comparative Study

Comparative sequence analysis of the inverted terminal repetitions from different adenoviruses

M Shinagawa et al. Proc Natl Acad Sci U S A. 1980 Jul.

Abstract

The comparative nucleotide sequences of the region of inverted terminal repetition from a representative member of group C (nononcogenic), group B (weakly oncogenic), and group A (highly oncogenic) adenoviruses are analyzed. Our data show that (i) the length of this unique region increases with the oncogenicity of the serotype, (ii) a unique homologous region--14 nucleotides long--is present exactly at the same distance from the terminus, and (iii) a hexanucleotide sequence, T-G-A-C-G-T, is present at the site where the terminal repetition diverges.

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