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. 1980 Jul;77(7):4247-50.
doi: 10.1073/pnas.77.7.4247.

HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus

I S Misko, D J Moss, J H Pope

HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus

I S Misko et al. Proc Natl Acad Sci U S A. 1980 Jul.

Abstract

The specificity of cytotoxic T cells generated in Epstein-Barr virus (EBV)-infected lymphocyte cultures was investigated, using a 51Cr release assay. Potent cytotoxic T cells with preferred specificity directed to antigens expressed on autologous lymphoblastoid cell line (LCL) target cells were present in 14-day cultures of lymphocytes from EBV-seropositive donors and not from seronegative donors. Moreover, the cytotoxic patterns obtained with a panel of HLA antigen-related and unrelated LCL target cells, supported by unlabeled target inhibition tests, strongly indicate that T cell cytotoxicity to EBV is restricted to HLA antigens.

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