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. 1980 Aug;77(8):4623-7.
doi: 10.1073/pnas.77.8.4623.

Solubilization of active opiate receptors

W F Simonds, G Koski, R A Streaty, L M Hjelmeland, W A Klee

Solubilization of active opiate receptors

W F Simonds et al. Proc Natl Acad Sci U S A. 1980 Aug.

Abstract

Receptors that reversibly bind opiates and opioid peptides have been solubilized from brain and neuroblastoma-glioma hybrid cell NG108-15 membranes. Active receptors are specifically solubilized with a new type of detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate, which is a zwitterionic derivative of cholic acid. The solubilized receptor complexes behave as large molecules with a Stokes radius of 70 A and contain protein as an essential constituent.

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References

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