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. 1980 Aug;77(8):4871-4.
doi: 10.1073/pnas.77.8.4871.

Germ-line reinsertions of AKR murine leukemia virus genomes in Akv-1 congenic mice

W P Rowe, C A Kozak

Germ-line reinsertions of AKR murine leukemia virus genomes in Akv-1 congenic mice

W P Rowe et al. Proc Natl Acad Sci U S A. 1980 Aug.

Abstract

Congenic mouse strains NIH,Akv-1 and NIH,Akv-2 carry the two high ecotropic virus-inducing loci of the AKR mouse on the NIH Swiss genetic background. Progeny tests of animals in three separate congenic families show that both Avk-1 and Akv-2 are stably transmitted as classical mendelian loci in these mice. However, during the process of inbreeding, additional chromosomal viral loci were detected in several NIH.Akv-1 sublines. These loci appeared only in the progeny of virus-positive females. They segregate with mendelian ratios, are unlinked to markers on chromsome 7 near Akv-1, and are phenotypically expressed as high-virus-inducing loci. The generation of new loci for viurs induction, no doubt resulting from the rare germ-line reintegration of the endogenous ectropic provirus, represents a unique form of gene duplication and rearrangement.

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