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Comparative Study
. 1980 Oct;8(4):447-9.
doi: 10.1002/ana.410080421.

C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor

E Chelmicka-Schorr, B G Arnason, S J Holshouser
Comparative Study

C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor

E Chelmicka-Schorr et al. Ann Neurol. 1980 Oct.

Abstract

Rat C-6 glioma possesses a beta-adrenergic receptor which, when activated, raises intracellular levels of cyclic adenosine monophosphate (cAMP) in cultured C-6 glioma cells. The present study shows that growth of C-6 glioma is suppressed in rats treated with the beta-adrenergic agonist isoproterenol. Addition of papaverine, a cAMP phosphodiesterase inhibitor, to the treatment schedule augments this effect. Pharmacological agents that elevate intracellular cAMP levels may retard the growth of neural tumors in vivo.

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