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. 1980 Oct;77(10):5799-801.
doi: 10.1073/pnas.77.10.5799.

Catabolite repression in Escherichia coli mutants lacking cyclic AMP receptor protein

C Guidi-Rontani, A Danchin, A Ullmann

Catabolite repression in Escherichia coli mutants lacking cyclic AMP receptor protein

C Guidi-Rontani et al. Proc Natl Acad Sci U S A. 1980 Oct.

Abstract

Pleiotropic carbohydrate-positive pseudorevertants have been isolated from a specific class of rho-crp double mutants of Escherichia coli carrying both defective transcription termination protein, rho, and cyclic AMP receptor protein. The modulation of catabolite repression of beta-galactosidase, amylomaltase, and tryptophanase has been studied in the pseudorevertants. It has been found that these mutants exhibit catabolite repression. Because catabolite-sensitive operons can be expressed in the absence of functional cyclic AMP receptor protein, this would suggest on the one hand that the cyclic AMP-receptor protein complex is not the exclusive mediator of catabolite repression and on the other hand that rho might be involved in the regulation of catabolite-sensitive operons.

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